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mitotane will minimize the level or impact of abemaciclib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of abemaciclib with robust CYP3A4 inducers minimizes plasma focus of abemaciclib and its metabolites.Metabolism Datopotamab deruxtecan-dlnk undergoes intracellular cleavage by l